Analytical Validation of a Novel MicroRNA Panel for Risk Stratification of Cognitive Impairment

Arzu Kunwar, Kenny Kwabena Ablordeppey, Alidad Mireskandari, Kira Sheinerman, Michael Kiefer, Samuil Umansky and Gyanendra Kumar. DiamiR Biosciences Laboratory, 2 Church Street South, Suite B05, New Haven, CT 06519, USA We have been developing a novel approach to identify cognitive impairment-related biomarkers by profiling brain-enriched and inflammation-associated microRNA (miRNA) in plasma specimens of cognitively unimpaired … Continued

Brain-enriched microRNAs circulating in plasma as novel biomarkers for Rett syndrome

Kira Sheinerman, Aleksandra Djukic, Vladimir G. Tsivinsky, and Samuil R. Umansky. PLOS ONE 14(7): e0218623 (2019) Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by mutations in the X-linked gene MECP2 (methyl-CpG-binding protein 2). Minimally invasive and accurate biomarkers of disease progression and treatment response could facilitate screening of therapeutic compounds in animal models, enrollment of … Continued

Aging and aging-associated diseases: a microRNA-based endocrine regulation hypothesis

Samuil Umansky.  Aging, Theory, 10(10): 2557-2569 (2018) Although there are numerous hypotheses explaining the nature of aging and associated processes, two concepts are dominant: (i) aging is a result of cell-autonomous processes, such as the accumulation of DNA mutations, aberrant methylations, protein defects, and shortening of telomeres, leading to either inhibition of cellular proliferation and death … Continued

Age- and sex-dependent changes in levels of circulating brain-enriched microRNAs during normal aging

Kira Sheinerman, Vladimir Tsivinsky, Aabhas Mathur, Debra Kessler, Beth Shaz and Samuil Umansky. Aging, Research, 10(10): 3017–3041 (2018) Aging is a major risk factor for many common and life-threatening pathologies. The development of reliable biomarkers of aging should lead to a better understanding of aging-associated processes and facilitate the development of therapeutic regimens that delay aging. … Continued

Circulating brain-enriched microRNAs as novel biomarkers for detection and differentiation of neurodegenerative diseases

Kira S. Sheinerman, Jon B. Toledo, Vladimir G. Tsivinsky, David Irwin, Murray Grossman, Daniel Weintraub, Howard I. Hurtig, Alice Chen-Plotkin, David A. Wolk, Leo F. McCluskey, Lauren B. Elman, John Q. Trojanowski and Samuil R. Umansky.  Alzheimer’s Research & Therapy, 9:89 (2017) Background: Minimally invasive specific biomarkers of neurodegenerative diseases (NDs) would facilitate patient selection … Continued

Universal screening test based on analysis of circulating organ-enriched microRNAs: a novel approach to diagnostic screening

Kira S Sheinerman and Samuil Umansky. Expert Review of Molecular Diagnostics, 3:329 (2015) Early disease detection leads to more effective and cost-efficient treatment. It is especially important for cancer and neurodegenerative diseases, because progression of these pathologies leads to significant and frequently irreversible changes in underlying pathophysiological processes. At the same time, the development of … Continued

Analysis of organ-enriched microRNAs in plasma as an approach to development of Universal Screening Test: feasibility study

Kira S. Sheinerman, Vladimir G. Tsivinsky and Samuil R. Umansky. Journal of Translational Medicine, 11:304 (2013) Background: Early disease detection with a minimally invasive screening test will significantly increase effectiveness and decrease the cost of treatment. Here we propose a framework of a novel approach – Universal Screening Test (UST) for the detection of pathological … Continued

Plasma microRNA biomarkers for detection of mild cognitive impairment: biomarker validation study

Kira S. Sheinerman, Vladimir G. Tsivinsky, Laila Abdullah, Fiona Crawford and Samuil R. Umansky. Aging, 5: 925-938 (2013) A minimally invasive test for early detection and monitoring of Alzheimer’s and other neurodegenerative diseases is a highly unmet need for drug development and planning of patient care. Mild Cognitive Impairment (MCI) is a syndrome characteristic of … Continued

Circulating cell-free microRNA as biomarkers for screening, diagnosis, and monitoring of neurodegenerative diseases and other neurologic pathologies

Kira S. Sheinerman and Samuil R. Umansky. Frontiers in Cellular Neuroscience, 7 : 00150 (2013) Many neurodegenerative diseases, such as Alzheimer’s disease, Parkinson disease, vascular and frontotemporal dementias, as well as other chronic neurological pathologies, are characterized by slow development with a long asymptomatic period followed by a stage with mild clinical symptoms. As a … Continued